Cost Plus Drugs review

Cost Plus Drugs, run by the Mark Cuban Cost Plus Drug Company, built its pitch around a simple formula and it shows the math on every product page. For a 30 count of 10mg atorvastatin, the page lists a $0.22 manufacturing cost, a $0.03 markup at 15% and a $5.00 pharmacy labor fee, for $5.25, next to a $55.20 retail price at other pharmacies. Standard shipping is added at checkout, $5.25 on the page we checked. There is no membership, so you only pay per prescription. The FAQ covers insurance, which it now accepts through some plans, PBMs and managed care organizations, plus auto-refill and caregiver profiles for children and adult dependents. The catalog is broad, with conditions from acid reflux to transplant care, but not every drug is carried, so search before you ask a prescriber to send a script. Because shipping is charged per order, consolidating refills or ordering 90-day supplies brings the effective cost down.

Who it is for

Cash payers and people with high copays who want to see exactly what they pay for each drug.

Price

Per prescription: drug cost plus 15% markup plus a $5 pharmacy labor fee; 30 count of 10mg atorvastatin is $5.25 before shipping.

Your Drug Price With Us $5.25 You save $49.95 on your medication
Quoted from the vendor pricing page on November 9, 2026.

Key features

• Every drug page breaks the price into manufacturing cost, 15% markup and pharmacy labor
• Pharmacy labor fee of $5.00 per prescription, with standard shipping added at checkout
• Shows a retail price at other pharmacies next to its own price
• Works with some insurance plans, PBMs and managed care organizations
• Auto-refill and caregiver accounts for children and adult dependents

Strengths and weaknesses

• Strength: The most transparent pricing we found: you see the markup in dollars
• Strength: Big savings on many generics compared with listed retail prices
• Strength: No membership fee
• Weakness: Standard shipping is charged on top, $5.25 on the drug page we checked
• Weakness: It does not stock every medication
• Weakness: Mail only, so there is no same-day pickup

Key facts

• Markup: 15% over cost
• Pharmacy labor fee: $5.00 per prescription
• Standard shipping: $5.25 on the page we checked
• Membership: None
• Example: Atorvastatin 10mg, 30 count: $5.25

Where it ranks

Cost Plus Drugs is No. 2 in our Best Online Pharmacies verdict.