Rocco & Roxie Stain & Odor Eliminator review

Rocco & Roxie is the strongest pick for pet owners. The company describes a professional strength bio-enzymatic formula whose enzymatic bacteria activate on contact with odors and stains and feed on ammonia crystals and organic matter until they are gone, and it carries the Carpet and Rug Institute Seal of Approval. Its FAQ gives a mattress instruction: spray or pour on the mattress and leave it to work. For older stains the brand suggests letting the product sit overnight, or for a couple of days, so it reaches deeper. Rocco & Roxie says the formula is chlorine free, color safe and safe around pets and children, and warns against using it in a steam cleaner because heat can deactivate the enzymes. A 32 oz bottle was $23.97 as a one-time purchase on the brand's store, with 15% off on subscription. We compared documented features and published prices and did not test it.

Who it is for

Pet owners dealing with repeat or older urine spots who want a widely reviewed enzyme spray.

Price

32 oz bottle $23.97 one-time on the Rocco & Roxie store; 15% off with subscription.

ONE-TIME PURCHASE$23.97
Quoted from the vendor pricing page on November 11, 2026.

Key features

• Bio-enzymatic formula with enzymatic bacteria that feed on ammonia crystals and organic matter
• Carpet and Rug Institute Seal of Approval
• Mattress-specific direction: spray or pour on and leave it to work
• Chlorine free and color safe; described as safe around pets and children
• 32 oz and gallon sizes

Strengths and weaknesses

• Strength: Gives a direct mattress instruction in its FAQ
• Strength: Old stains can be left overnight or a couple of days
• Strength: Backed by a 60-day money-back policy on the brand store
• Weakness: Highest 32 oz price of the verified picks
• Weakness: Should not go in a steam cleaner, since heat can deactivate the enzymes
• Weakness: Full routine includes rinsing and extracting, which is harder on a mattress than a carpet

Key facts

• Price: $23.97 for 32 oz
• Formula: Bio-enzymatic
• Certification: CRI Seal of Approval
• Money-back window: 60 days

Where it ranks

Rocco & Roxie Stain & Odor Eliminator is No. 2 in our Best Mattress Stain and Urine Cleaners verdict.